Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50000309
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50245875(CHEMBL4086961)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of BACE-1 (unknown origin) using APP derived polypeptide harboring Lys-Met/Asn-Leu mutation as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50245874(CHEMBL4078371)
Affinity DataIC50: 115nMAssay Description:Inhibition of BACE-1 (unknown origin) using APP derived polypeptide harboring Lys-Met/Asn-Leu mutation as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50012632(CHEMBL2333941)
Affinity DataIC50: 240nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50012632(CHEMBL2333941)
Affinity DataIC50: 300nMAssay Description:Inhibition of BACE-1 in HEK293 cells expressing human APP751 cDNA harboring N670L671 mutation pretreated for 2 hrs followed by measuring after 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50245902(CHEMBL4090604)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human BACE-1 preincubated for 1 hr followed by substrate addition measured after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50245862(CHEMBL4062641)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human BACE-1 preincubated for 1 hr followed by substrate addition measured after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50245851(Spiclomazine)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human BACE-1 preincubated for 1 hr followed by substrate addition measured after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of recombinant human GSK3beta using prephosphorylated polypeptide as substrate preincubated for 30 mins followed by addition of kinase-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50138465(CHEMBL3752684)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of BACE-1 (unknown origin) using peptide mimicking APP sequence as substrate preincubated for 1 hr followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50245872(CHEMBL4096411)
Affinity DataIC50: 3.03E+4nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMed