Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50000770
TargetProstaglandin G/H synthase 2(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataIC50: 50nMAssay Description:Non noncompetitive inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataIC50: 150nMAssay Description:Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50038649(ML-3000 | [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phen...)
Affinity DataIC50: 160nMAssay Description:Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50038649(ML-3000 | [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phen...)
Affinity DataIC50: 370nMAssay Description:Non noncompetitive inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 870nMAssay Description:Non noncompetitive inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50260298(CHEMBL4075687)
Affinity DataIC50: 1.49E+4nMAssay Description:Non noncompetitive inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50260298(CHEMBL4075687)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50260298(CHEMBL4075687)
Affinity DataKi:  920nMAssay Description:Non noncompetitive inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed