Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50000110
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50397663(CHEMBL2181817)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 30 mins in presence of NADPH-generating system followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50397663(CHEMBL2181817)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50110590(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50240713(CHEMBL4066318)
Affinity DataKi:  22nMAssay Description:Reversible inhibition of CYP2C8 in human liver microsomes after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50240713(CHEMBL4066318)
Affinity DataKi:  52nMAssay Description:Time dependent inhibition of CYP2C8 in human liver microsomes after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50088513(CHEMBL3526940)
Affinity DataKi:  9.90E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 30 mins followed by substrate addition measured after 2 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50397663(CHEMBL2181817)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 2 to 40 mins measured after 2 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50397663(CHEMBL2181817)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 2 to 40 mins followed by NADPH-generating system additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50240713(CHEMBL4066318)
Affinity DataKi:  5.46E+4nMAssay Description:Inactivation of CYP1A2 in human liver microsomes after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed