Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50000546
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253041(CHEMBL4059597)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataEC50:  960nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253042(CHEMBL4060968)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253043(CHEMBL4071387)
Affinity DataEC50:  6.50E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 45nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5C expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5B expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253042(CHEMBL4060968)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253042(CHEMBL4060968)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253041(CHEMBL4059597)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253041(CHEMBL4059597)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253043(CHEMBL4071387)
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281129(US10022354, Example 69)
Affinity DataIC50: 105nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281121(US10022354, Example 61)
Affinity DataIC50: 122nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281067(US10022354, Example 7)
Affinity DataIC50: 128nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253041(CHEMBL4059597)
Affinity DataIC50: 180nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253064(CHEMBL4089789)
Affinity DataIC50: 198nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253037(CHEMBL4061676)
Affinity DataIC50: 204nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253036(CHEMBL4081928)
Affinity DataIC50: 251nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281130(US10022354, Example 70)
Affinity DataIC50: 265nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281107(US10022354, Example 47)
Affinity DataIC50: 357nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281106(US10022354, Example 46)
Affinity DataIC50: 458nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281131(US10022354, Example 71)
Affinity DataIC50: 469nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281119(US10022354, Example 59)
Affinity DataIC50: 727nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 770nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281105(US10022354, Example 45)
Affinity DataIC50: 878nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281108(US10022354, Example 48)
Affinity DataIC50: 897nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253035(CHEMBL4099924)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281114(US10022354, Example 54)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253058(CHEMBL4098317)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253067(CHEMBL4100491)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281065(US10022354, Example 5)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281096(US10022354, Example 36)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281112(US10022354, Example 52)
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281118(US10022354, Example 58)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 6A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM6A expressed in baculovirus infected Sf9 insect cells using H3K27me3 peptide as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253060(CHEMBL4074276)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253061(CHEMBL4082751)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 2B(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM2B expressed in baculovirus infected Sf9 insect cells using H3K36me2 peptide as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetHistone lysine demethylase PHF8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM7B expressed in baculovirus infected Sf9 insect cells using H3K9me1 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253065(CHEMBL4060733)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50253066(CHEMBL4068553)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
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