Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50000037
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239493(CHEMBL4103497 | US10329302, Example 312 | US107935...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239491(CHEMBL4083655 | US10329302, Example 173 | US107935...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239506(CHEMBL4071526 | US10329302, Example 188 | US107935...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production by measuring plasma protein binding corrected IC50 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as reduction R848-induced IL-6 secretion by measuring plasma protein binding corrected IC50 preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239497(CHEMBL4084228 | US10329302, Example 271 | US107935...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239492(CHEMBL4070515 | US10329302, Example 211 | US107935...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239505(CHEMBL4061801 | US10329302, Example 248 | US107935...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239496(CHEMBL4075552 | US10329302, Example 264 | US107935...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239504(CHEMBL4061890 | US10329302, Example 262 | US107935...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50: 9nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50: 13nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50: 17nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50: 24nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239493(CHEMBL4103497 | US10329302, Example 312 | US107935...)
Affinity DataIC50: 28nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50: 29nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239506(CHEMBL4071526 | US10329302, Example 188 | US107935...)
Affinity DataIC50: 30nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239491(CHEMBL4083655 | US10329302, Example 173 | US107935...)
Affinity DataIC50: 37nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239497(CHEMBL4084228 | US10329302, Example 271 | US107935...)
Affinity DataIC50: 52nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239492(CHEMBL4070515 | US10329302, Example 211 | US107935...)
Affinity DataIC50: 52nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239509(CHEMBL4086222)
Affinity DataIC50: 72nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239505(CHEMBL4061801 | US10329302, Example 248 | US107935...)
Affinity DataIC50: 87nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239496(CHEMBL4075552 | US10329302, Example 264 | US107935...)
Affinity DataIC50: 115nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239487(CHEMBL4089619)
Affinity DataIC50: 121nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 133nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239503(CHEMBL4061493)
Affinity DataIC50: 146nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 347nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)
Affinity DataIC50: 373nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50: 672nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239510(CHEMBL4064661 | US10329302, Example 32 | US1079357...)
Affinity DataIC50: 840nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239487(CHEMBL4089619)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239502(CHEMBL4104133)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239504(CHEMBL4061890 | US10329302, Example 262 | US107935...)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50: 2.84E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of human recombinant VEGFR2 using CAGAGAIETDKEYYTVKD as substrate after 60 mins by Lance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239501(CHEMBL4093989)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)