Compile Data Set for Download or QSAR
Report error Found 56 Enz. Inhib. hit(s) with all data for entry = 50001015
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at recombinant human P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at recombinant human P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at recombinant human P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity at recombinant human P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at P2X7 in human whole blood assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor(Rhesus macaque)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at macaque P2X7 assessed as inhibition of BzATP-induced calcium flux preincubated for 30 mins followed by BzATP addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 8.30nMAssay Description:Antagonist activity at recombinant human P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 9.10nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at P2X7 in rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50267791(AZD-9056 | AZD9056)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at mouse P2X7 assessed as inhibition of BzATP-induced calcium flux preincubated for 30 mins followed by BzATP addition measured o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at P2X7 in human PBMC assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at P2X7 in mouse whole blood assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254258(US9464084, 148 | US10112937, Example 148 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US9464084, 158 | US10112937, Example 158 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254189(US9464084, 74 | US10112937, Example 74 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254332(US9464084, 235 | US10112937, Example 235 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
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