Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50000181
TargetVascular endothelial growth factor receptor 2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 0.0860nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of FLT3 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of c-MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 3.90nMAssay Description:Competitive inhibition of c-MET (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of KIT (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of RET (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of KIT (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 10nMAssay Description:Inhibition of RET (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 18nMAssay Description:Inhibition of FLT3 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 28nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 44nMAssay Description:Inhibition of EGFR (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 55nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242033(CHEMBL4076054)
Affinity DataIC50: 95nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 144nMAssay Description:Inhibition of KIT (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 172nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 180nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 225nMAssay Description:Inhibition of EGFR (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242032(CHEMBL4067036)
Affinity DataIC50: 235nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242037(CHEMBL4080577)
Affinity DataIC50: 237nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242027(CHEMBL4079666)
Affinity DataIC50: 258nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242029(CHEMBL4088444)
Affinity DataIC50: 278nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 279nMAssay Description:Inhibition of KIT (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 387nMAssay Description:Inhibition of RET (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242023(CHEMBL4086090)
Affinity DataIC50: 455nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242025(CHEMBL4096249)
Affinity DataIC50: 457nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 594nMAssay Description:Inhibition of RET (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242034(CHEMBL4078720)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242024(CHEMBL4104011)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242022(CHEMBL4104302)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of FLT3 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242036(CHEMBL4096166)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242031(CHEMBL4098613)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242026(CHEMBL4094985)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242028(CHEMBL4068880)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242035(CHEMBL4078198)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50242030(CHEMBL4060214)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant c-MET (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed