Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50049132
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235018(CHEMBL4072070)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176693(US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176709(US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176724(US9688710, 146 (3R,4R,5S,6R)-2-(3-(4-(3-((3-(dimet...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176697(US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176709(US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176414(US9688710, 13 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176414(US9688710, 13 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176724(US9688710, 146 (3R,4R,5S,6R)-2-(3-(4-(3-((3-(dimet...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176714(US9688710, 136 N-(1-((2-(dimethylamino)ethyl)amino...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176544(US9688710, 104 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235018(CHEMBL4072070)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176697(US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176701(US9688710, 124 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176693(US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176712(US9688710, 135 (3R,4R,5S,6R)-2-(3-(4-(3-((1-hydrox...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176714(US9688710, 136 N-(1-((2-(dimethylamino)ethyl)amino...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176725(US9688710, 147 N-(2-methyl-1-((1-methylpiperidin-4...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176446(US9688710, 45 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176706(US9688710, 129 2-methyl-2-((4-(4-(2-methyl-5-((2S,...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176712(US9688710, 135 (3R,4R,5S,6R)-2-(3-(4-(3-((1-hydrox...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176704(US9688710, 127 N-(2,2-dimethyl-3-(4-methylpiperazi...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176544(US9688710, 104 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176446(US9688710, 45 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176727(US9688710, 149 1-(1-hydroxy-2-methylpropan-2-yl)-3...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176725(US9688710, 147 N-(2-methyl-1-((1-methylpiperidin-4...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176403(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176438(US9688710, 37 2-methyl-2-(2-(4-(2-methyl-5-((2S,3R...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176704(US9688710, 127 N-(2,2-dimethyl-3-(4-methylpiperazi...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176701(US9688710, 124 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176405(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176405(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176706(US9688710, 129 2-methyl-2-((4-(4-(2-methyl-5-((2S,...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176438(US9688710, 37 2-methyl-2-(2-(4-(2-methyl-5-((2S,3R...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50: 36nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176727(US9688710, 149 1-(1-hydroxy-2-methylpropan-2-yl)-3...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176403(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2019
Entry Details Article
PubMed