Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50049076
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234075(CHEMBL4063438)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234081(CHEMBL4077611)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234079(CHEMBL4096048 | US9701664, Example 80)
Affinity DataKd:  38nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234079(CHEMBL4096048 | US9701664, Example 80)
Affinity DataKd:  38nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234082(CHEMBL4088624 | US9701664, Example 52)
Affinity DataKd:  30nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataKd:  44nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataKd:  38nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234077(CHEMBL4066791)
Affinity DataKd: <1.00E+3nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234076(CHEMBL4077078)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234076(CHEMBL4077078)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234072(CHEMBL4099031)
Affinity DataKd:  18nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234075(CHEMBL4063438)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataKd:  44nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50379276(CHEMBL1230119)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234072(CHEMBL4099031)
Affinity DataKd:  18nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234077(CHEMBL4066791)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataKd:  38nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234082(CHEMBL4088624 | US9701664, Example 52)
Affinity DataKd:  30nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50379276(CHEMBL1230119)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234081(CHEMBL4077611)
Affinity DataKd: <1.00E+3nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234073(CHEMBL4063330 | US9701664, Example 1)
Affinity DataIC50: 12nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234073(CHEMBL4063330 | US9701664, Example 1)
Affinity DataIC50: 12nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataIC50: 19nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataIC50: 19nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234085(CHEMBL4102297 | US9701664, Example 89)
Affinity DataIC50: 26nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234085(CHEMBL4102297 | US9701664, Example 89)
Affinity DataIC50: 26nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataIC50: 40nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSPA1A mRNA level preincubated for 1 hr followed by 17-AAG ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataIC50: 40nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSPA1A mRNA level preincubated for 1 hr followed by 17-AAG ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234090(CHEMBL4069552 | US9701664, Example 2)
Affinity DataIC50: 51nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234090(CHEMBL4069552 | US9701664, Example 2)
Affinity DataIC50: 51nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 68nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 68nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234083(CHEMBL4070302 | US9701664, Example 81)
Affinity DataIC50: 115nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234083(CHEMBL4070302 | US9701664, Example 81)
Affinity DataIC50: 120nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234079(CHEMBL4096048 | US9701664, Example 80)
Affinity DataIC50: 220nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234079(CHEMBL4096048 | US9701664, Example 80)
Affinity DataIC50: 224nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 417nMAssay Description:Inhibition of full length human recombinant GST-tagged BRAF (S429 to E741 residues) expressed in baculovirus expression system using Ser/Thr 03 mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 420nMAssay Description:Inhibition of full length human recombinant GST-tagged BRAF (S429 to E741 residues) expressed in baculovirus expression system using Ser/Thr 03 mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234076(CHEMBL4077078)
Affinity DataIC50: 447nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234076(CHEMBL4077078)
Affinity DataIC50: 450nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234072(CHEMBL4099031)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234072(CHEMBL4099031)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant His tagged PDGFRB cytoplasmic domain (556 to 1108 residues) expressed in baculovirus expression system using Tyr 04 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KIT (unknown origin) using Tyr 06 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KIT (unknown origin) using Tyr 06 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234086(CHEMBL4082534)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
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