Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50000725
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50259713(CHEMBL4095303)
Affinity DataEC50:  1.01E+4nMAssay Description:Partial agonist activity at human alpha4beta2 nAChR expressed in GH4CL cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50194315((S)-2-((R)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-1-...)
Affinity DataIC50: 2.78E+3nMAssay Description:Antagonist activity at human alpha3beta4 nAChR expressed in GH4CL cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50194315((S)-2-((R)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-1-...)
Affinity DataIC50: 5.36E+3nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in GH4CL cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50259714(CHEMBL4101001)
Affinity DataKi:  160nMAssay Description:Displacement of [3H](-)cytisine from rat whole brain alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50113482(CHEMBL3603941)
Affinity DataKi:  257nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  261nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50114015(CHEMBL3603939)
Affinity DataKi:  271nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50357065(CHEMBL1917232)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50194315((S)-2-((R)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-1-...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50259712(CHEMBL4061221)
Affinity DataKi:  5.80E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50256279((2S,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...)
Affinity DataKi:  8.20E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50259715(CHEMBL4076895)
Affinity DataKi:  8.90E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50259713(CHEMBL4095303)
Affinity DataKi:  1.62E+4nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50259716(CHEMBL4074865)
Affinity DataKi:  2.20E+4nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed