Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50047874
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191064(CHEMBL3894220)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190797(CHEMBL3974590)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190804(CHEMBL3966074)
Affinity DataIC50: 64nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191067(CHEMBL3963395)
Affinity DataIC50: 78nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190797(CHEMBL3974590)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190917(CHEMBL3918589)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191061(CHEMBL3893653)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190797(CHEMBL3974590)
Affinity DataIC50: 87nMAssay Description:Antagonist activity at P2X7 receptor in human whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-stimulate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 103nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191063(CHEMBL3982581)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190804(CHEMBL3966074)
Affinity DataIC50: 123nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190804(CHEMBL3966074)
Affinity DataIC50: 141nMAssay Description:Antagonist activity at P2X7 receptor in human whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-stimulate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190911(CHEMBL3903665)
Affinity DataIC50: 151nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190917(CHEMBL3918589)
Affinity DataIC50: 305nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190797(CHEMBL3974590)
Affinity DataIC50: 316nMAssay Description:Antagonist activity at P2X7 receptor in C57/bl6 mouse whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 376nMAssay Description:Antagonist activity at P2X7 receptor in human whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-stimulate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191061(CHEMBL3893653)
Affinity DataIC50: 486nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190804(CHEMBL3966074)
Affinity DataIC50: 631nMAssay Description:Antagonist activity at P2X7 receptor in C57/bl6 mouse whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 631nMAssay Description:Antagonist activity at P2X7 receptor in C57/bl6 mouse whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191064(CHEMBL3894220)
Affinity DataIC50: 1.09E+3nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed