Compile Data Set for Download or QSAR
Report error Found 117 Enz. Inhib. hit(s) with all data for entry = 50009923
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-6,6-fused heteroaryl-sulfonamide derivative from human Nav1.7 expressed in HEK293 cell membranes preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533564(CHEMBL4576210)
Affinity DataIC50: 28nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329015(US9663508, Example 348 | 4-(5-chloro-6-(3,5-dichlo...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as use-dependent block at pulse 26 by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as tonic block at pulse 1 by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current by manual whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Nav1.7 at 20% inactivated state expressed in HEK293 cells at -140 mV holding potential followed by channel inactivation by manual...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329034(US9663508, Example 382 | 4-(6-(3,5-dichlorophenoxy...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533561(CHEMBL4459021)
Affinity DataIC50: 62nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50272533(CHEMBL4129030)
Affinity DataIC50: 76nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329062(US9663508, Example 547 | 4-(5-cyano-6-(3,5-dichlor...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329017(US9663508, Example 355 | 4-(5-chloro-6-((2S)-2-(1-...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329021(US9663508, Example 363 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329075(US9663508, Example 576 | 4-(5-chloro-6-((4-chlorob...)
Affinity DataIC50: 109nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329200(US9663508, Example 702 | 4-(5-chloro-6-(cyclobutyl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 115nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533540(CHEMBL4539119)
Affinity DataIC50: 140nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533545(CHEMBL4571566)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533543(CHEMBL4530399)
Affinity DataIC50: 160nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533546(CHEMBL4462738)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533565(CHEMBL4558539)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533557(CHEMBL4517426)
Affinity DataIC50: 260nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 270nMAssay Description:Inhibition of Nav1.7 in C57BL/6 mouse DRG neurons assessed as reduction in native TTX-S current amplitude by manual patch clamp electrophysiology ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533551(CHEMBL4459478)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533549(CHEMBL4579742)
Affinity DataIC50: 280nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533544(CHEMBL4444511)
Affinity DataIC50: 290nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533558(CHEMBL4474441)
Affinity DataIC50: 350nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533554(CHEMBL4470763)
Affinity DataIC50: 530nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533560(CHEMBL4590389)
Affinity DataIC50: 550nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM154061(US9012443, 57)
Affinity DataIC50: 590nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533566(CHEMBL4443414)
Affinity DataIC50: 660nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533547(CHEMBL4537339)
Affinity DataIC50: 740nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells assessed as reduction in peak inward current by manual whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533550(CHEMBL4445360)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533562(CHEMBL4470095)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533552(CHEMBL4450471)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533563(CHEMBL4467379)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533564(CHEMBL4576210)
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329017(US9663508, Example 355 | 4-(5-chloro-6-((2S)-2-(1-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533553(CHEMBL4445237)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533542(CHEMBL4460250)
Affinity DataIC50: 3.04E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533551(CHEMBL4459478)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 3.69E+3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK293T cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533540(CHEMBL4539119)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533562(CHEMBL4470095)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329015(US9663508, Example 348 | 4-(5-chloro-6-(3,5-dichlo...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329203(US9663508, Example 705 | 4-(5-chloro-6-(2,5-difluo...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells assessed as reduction in peak inward current by manual whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533546(CHEMBL4462738)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
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