Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50047945
TargetAurora kinase B(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  10nMAssay Description:Binding affinity to human Aurora B kinase expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to human YSK4 expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  5nMAssay Description:Binding affinity to human Aurora A kinase expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase C(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  11nMAssay Description:Binding affinity to human Aurora C kinase expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDeath-associated protein kinase 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  450nMAssay Description:Binding affinity to human DAPK2 expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of Aurora A kinase in human HeLa Kyoto cells assessed as induction of defective chromosome alignment during metaphase incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to human PIK3CG expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  480nMAssay Description:Binding affinity to human PIP5K2C expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataKd:  120nMAssay Description:Binding affinity to auto-inhibited human CSF1R expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198081(CHEMBL3915550)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198080(CHEMBL3932394)
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198082(CHEMBL3904239)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198086(CHEMBL3985313)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50: 10nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198052(CHEMBL3896597)
Affinity DataIC50: 24nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198052(CHEMBL3896597)
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198044(CHEMBL3903187)
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198045(CHEMBL3975102)
Affinity DataIC50: 130nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50: 150nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198078(CHEMBL3941377)
Affinity DataIC50: 190nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198079(CHEMBL3924918)
Affinity DataIC50: 190nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198084(CHEMBL3913242)
Affinity DataIC50: 220nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50: 300nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198077(CHEMBL3951166)
Affinity DataIC50: 300nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198076(CHEMBL3939478)
Affinity DataIC50: 370nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198042(CHEMBL3935395)
Affinity DataIC50: 380nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198041(CHEMBL3984254)
Affinity DataIC50: 390nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198152(CHEMBL3923442)
Affinity DataIC50: 430nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198048(CHEMBL3941909)
Affinity DataIC50: 480nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198043(CHEMBL3983087)
Affinity DataIC50: 600nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50: 760nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198162(CHEMBL3938394)
Affinity DataIC50: 780nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198044(CHEMBL3903187)
Affinity DataIC50: 830nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198153(CHEMBL3924626)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198086(CHEMBL3985313)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198027(CHEMBL3921246)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198082(CHEMBL3904239)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198046(CHEMBL3911508)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase B/Inner centromere protein(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198081(CHEMBL3915550)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198159(CHEMBL3956916)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198074(CHEMBL3914435)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50198154(CHEMBL3949078)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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