Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50035807
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  1.60nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018230(CHEMBL36583 | 2-(4-Methylcarbamoyloxy-phenyl)-2-ph...)
Affinity DataKi:  2nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018229(CHEMBL37372 | 2-(4-Hydroxy-phenyl)-2-phenyl-propio...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018230(CHEMBL36583 | 2-(4-Methylcarbamoyloxy-phenyl)-2-ph...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018225(CHEMBL416974 | 2-(4-Dimethylcarbamoyloxy-phenyl)-2...)
Affinity DataKi:  42nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  51nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018229(CHEMBL37372 | 2-(4-Hydroxy-phenyl)-2-phenyl-propio...)
Affinity DataKi:  100nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM39341(PIRENZEPINE DIHYDROCHLORIDE | SMR000058502 | MLS00...)
Affinity DataKi:  120nMAssay Description:Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018225(CHEMBL416974 | 2-(4-Dimethylcarbamoyloxy-phenyl)-2...)
Affinity DataKi:  150nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM39341(PIRENZEPINE DIHYDROCHLORIDE | SMR000058502 | MLS00...)
Affinity DataKi:  170nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018226(CHEMBL288482 | 2-(4-Dimethylcarbamoyloxy-phenyl)-2...)
Affinity DataKi:  800nMAssay Description:Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018225(CHEMBL416974 | 2-(4-Dimethylcarbamoyloxy-phenyl)-2...)
Affinity DataKi:  1.30E+3nMAssay Description:Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018230(CHEMBL36583 | 2-(4-Methylcarbamoyloxy-phenyl)-2-ph...)
Affinity DataKi:  1.40E+3nMAssay Description:Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018227(CHEMBL39342 | 2,2-Bis-(4-hydroxy-phenyl)-propionic...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018226(CHEMBL288482 | 2-(4-Dimethylcarbamoyloxy-phenyl)-2...)
Affinity DataKi:  2.40E+3nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018226(CHEMBL288482 | 2-(4-Dimethylcarbamoyloxy-phenyl)-2...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50313079(Mestinon | Regonol | Pyridostigmine | CHEMBL812 | ...)
Affinity DataKi:  3.50E+3nMAssay Description:Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018228(CHEMBL290912 | 2,2-Bis-(4-dimethylcarbamoyloxy-phe...)
Affinity DataKi:  4.60E+3nMAssay Description:Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50018227(CHEMBL39342 | 2,2-Bis-(4-hydroxy-phenyl)-propionic...)
Affinity DataKi:  4.90E+3nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataKi:  5.00E+3nMAssay Description:Anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed