Compile Data Set for Download or QSAR
Report error Found 191 Enz. Inhib. hit(s) with all data for entry = 50010198
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459018(CHEMBL4166405)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535970(CHEMBL4569967)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459007(CHEMBL4218734)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 5nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535971(CHEMBL4593348)
Affinity DataIC50: 8nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459011(CHEMBL4215266)
Affinity DataIC50: 10nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535995(CHEMBL4517663)
Affinity DataIC50: 19nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50: 21nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459018(CHEMBL4166405)
Affinity DataIC50: 33nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535990(CHEMBL4527822)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50536001(CHEMBL4576302)
Affinity DataIC50: 39nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535966(CHEMBL4560522)
Affinity DataIC50: 45nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 45nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459007(CHEMBL4218734)
Affinity DataIC50: 46nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535990(CHEMBL4527822)
Affinity DataIC50: 49nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535982(CHEMBL4567042)
Affinity DataIC50: 50nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535979(CHEMBL4533539)
Affinity DataIC50: 52nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535994(CHEMBL4548927)
Affinity DataIC50: 63nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50536000(CHEMBL4519670)
Affinity DataIC50: 70nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535969(CHEMBL4543897)
Affinity DataIC50: 73nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535974(CHEMBL4563993)
Affinity DataIC50: 73nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535981(CHEMBL4588822)
Affinity DataIC50: 87nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535971(CHEMBL4593348)
Affinity DataIC50: 98nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 109nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535990(CHEMBL4527822)
Affinity DataIC50: 109nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50536004(CHEMBL4591401)
Affinity DataIC50: 124nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535980(CHEMBL4514524)
Affinity DataIC50: 132nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 133nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535977(CHEMBL4578468)
Affinity DataIC50: 137nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535990(CHEMBL4527822)
Affinity DataIC50: 139nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535970(CHEMBL4569967)
Affinity DataIC50: 149nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535985(CHEMBL4548199)
Affinity DataIC50: 168nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535972(CHEMBL4565988)
Affinity DataIC50: 181nMAssay Description:Inhibition of C-terminal FLAG-tagged recombinant mTOR (1362 to 2549 residues) (unknown origin) using Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 183nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535970(CHEMBL4569967)
Affinity DataIC50: 204nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535990(CHEMBL4527822)
Affinity DataIC50: 204nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535971(CHEMBL4593348)
Affinity DataIC50: 247nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535991(CHEMBL4543599)
Affinity DataIC50: 360nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50459018(CHEMBL4166405)
Affinity DataIC50: 370nMAssay Description:Inhibition of DNAPK (unknown origin) using p53-based peptide substrate preincubated for 5 min prior to ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535999(CHEMBL4551177)
Affinity DataIC50: 373nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535984(CHEMBL4569880)
Affinity DataIC50: 418nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50459018(CHEMBL4166405)
Affinity DataIC50: 445nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50535970(CHEMBL4569967)
Affinity DataIC50: 452nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535998(CHEMBL4550293)
Affinity DataIC50: 456nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50208517(KU-55933 | 2-morpholin-4-yl-6-thianthren-1-yl-pyra...)
Affinity DataIC50: 458nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2/ATP as substrate incubated for 20 mins followed by substrate addition by Kinase Glo reagent base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535996(CHEMBL4549865)
Affinity DataIC50: 525nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
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