Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50047648
TargetSynapsin-1(Bovine)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM23408(2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-ch...)
Affinity DataIC50: 150nMAssay Description:Inhibition of bovine brain synapsin-1 incubated for 1 hr by ATP-[gamma35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSynapsin-1(Bovine)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50180856(CHEMBL3818384)
Affinity DataIC50: 500nMAssay Description:Inhibition of bovine brain synapsin-1 incubated for 1 hr by ATP-[gamma35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataIC50: 930nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSynapsin-1(Bovine)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bovine brain synapsin-1 incubated for 1 hr by ATP-[gamma35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 5.87E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50445351(NAMOLINE)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of GST-tagged LSD1 (2 to 852 residues) (unknown origin) using H3K4me2 substrate assessed as reduction in H2O2 production by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM26197(Paracetamol | acetaminophen | CHEMBL112 | N-(4-hyd...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human recombinant COX1 expressed in Sf9 cell microsomes assessed as reduction in conversion of arachidonic acid to PGE2 incubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human recombinant COX1 expressed in Sf9 cell microsomes assessed as reduction in conversion of arachidonic acid to PGE2 incubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataIC50: 9.50E+5nMAssay Description:Inhibition of human recombinant COX1 expressed in Sf9 cell microsomes assessed as reduction in conversion of arachidonic acid to PGE2 incubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed