Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50047589
Target14-3-3 protein beta/alpha(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177028(CHEMBL3814675)
Affinity DataKd:  70nMAssay Description:Binding affinity to GST-tagged 125I-labelled 14-3-3beta (unknown origin) expressed in Escherichia coli by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
Target14-3-3 protein theta(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177028(CHEMBL3814675)
Affinity DataKd:  70nMAssay Description:Binding affinity to GST-tagged 125I-labelled full length human 14-3-3tau expressed in Escherichia coli by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
Target14-3-3 protein eta(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177028(CHEMBL3814675)
Affinity DataKd:  70nMAssay Description:Binding affinity to GST-tagged 125I-labelled 14-3-3eta (unknown origin) expressed in Escherichia coli by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177029(CHEMBL3814269)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human Plk2 PBD (355 to 685 residues) using 5-carboxyfluorescein-GPMQTSpTPKNG-OH as substrate incubated for 1 hr prior to addition of su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177029(CHEMBL3814269)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human Plk3 PBD (335 to 646 residues) using 5-carboxyfluorescein-GPLATSpTPKNG-OH as substrate incubated for 1 hr prior to addition of su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177029(CHEMBL3814269)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human Plk1 PBD (326 to 603 residues) using 5-carboxyfluorescein-GPMQSpTPLNG-OH as substrate incubated for 1 hr prior to addition of sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
Target14-3-3 protein sigma(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50177030(CHEMBL3813927)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 14-3-3sigma (unknown origin) assessed as reduction in 14-3-3sigma- mediated increase in MMP1 mRNA by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)