Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50047474
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.00500nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human S1P3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.377nMAssay Description:Agonist activity at human S1P1 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.901nMAssay Description:Agonist activity at human S1P1 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.0700nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.114nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.00560nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  8.20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  3.60nMAssay Description:Agonist activity at human S1P3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.00600nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human S1P5 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human S1P5 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at human S1P4 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human S1P4 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50: 0.0100nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataIC50: 0.0140nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human S1P3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed