Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50047644
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50180838(CHEMBL3818606)
Affinity DataIC50: 0.00715nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50180834(CHEMBL3819302)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50180836(CHEMBL3818677)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50180837(CHEMBL3819622)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 13nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataIC50: 15nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Mouse)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50180839(CHEMBL1998165)
Affinity DataIC50: 20nMAssay Description:Inhibition of MEK1 in mouse C26 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 1 hr by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50180835(CHEMBL3819520)
Affinity DataIC50: 57nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed