Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50047181
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152667(CHEMBL3780636)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152602(CHEMBL3781442)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152666(CHEMBL3781359)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152668(CHEMBL3779913)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152665(CHEMBL3781394)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152601(CHEMBL3780467)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152607(CHEMBL3780230)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152603(CHEMBL3780299)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152600(CHEMBL3779939)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152671(CHEMBL3781196)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 2nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase BRSK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 2nMAssay Description:Inhibition of BRSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152608(CHEMBL3780647)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152596(CHEMBL3781427)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK1 in human PBMC cells assessed as inhibition of IL-6-induced MCP1 secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152606(CHEMBL3781767)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152669(CHEMBL3779924)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 4nMAssay Description:Inhibition of SNF1LK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152596(CHEMBL3781427)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152673(CHEMBL3780485)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152672(CHEMBL3781791)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of AMPKa1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152605(CHEMBL3780977)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50152601(CHEMBL3780467)
Affinity DataIC50: 7nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152599(CHEMBL3781476)
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152598(CHEMBL3780249)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2 in human CD34+ cells assessed as inhibition of EPO-mediated cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50152596(CHEMBL3781427)
Affinity DataIC50: 9nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 9nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152674(CHEMBL3780897)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 13nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152604(CHEMBL3781636)
Affinity DataIC50: 13nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152596(CHEMBL3781427)
Affinity DataIC50: 17nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152601(CHEMBL3780467)
Affinity DataIC50: 17nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152597(CHEMBL3782012)
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152670(CHEMBL3781876)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50152601(CHEMBL3780467)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1 in human PBMC cells assessed as inhibition of IL-6-induced MCP1 secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
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