Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50009804
TargetBifunctional epoxide hydrolase 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50264106(CHEMBL3818875)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human recombinant sEH using 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid as substrate assessed as formation of 14,15-dihydroxy-5Z,8Z,11Zei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50264106(CHEMBL3818875)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human recombinant sEH using 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid as substrate assessed as formation of 14,15-dihydroxy-5Z,8Z,11Zei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target2',5'-phosphodiesterase 12(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532283(CHEMBL4556129)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human PDE12 (17 to 609 residues) expresssed in Escherichia coli BL21(DE3) cells using 2-5A as substrate assessed as AMP monomers and AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target2',5'-phosphodiesterase 12(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532283(CHEMBL4556129)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human PDE12 (17 to 609 residues) expresssed in Escherichia coli BL21(DE3) cells using 2-5A as substrate assessed as AMP monomers and AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532278(CHEMBL4452411)
Affinity DataIC50: 2nMAssay Description:Competitive inhibition of N-terminal His-tagged human recombinant sEH expressed in insect Sf21 cells using Epoxy Fluor 7 as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532278(CHEMBL4452411)
Affinity DataIC50: 2nMAssay Description:Competitive inhibition of N-terminal His-tagged human recombinant sEH expressed in insect Sf21 cells using Epoxy Fluor 7 as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532280(CHEMBL4465847)
Affinity DataIC50: 4nMAssay Description:Inhibition of chicken Src kinase domain using AEEEIYGEFAKKK as substrate by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532280(CHEMBL4465847)
Affinity DataIC50: 4nMAssay Description:Inhibition of chicken Src kinase domain using AEEEIYGEFAKKK as substrate by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein phosphatase 1D(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50118478(CHEMBL3613749)
Affinity DataIC50: 6nMAssay Description:Inhibition of human Wip1 (2 to 420 residues) expressed in baculovirus-infected insect SF9 cells assessed as fluorescein diphosphate hydrolysis after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein phosphatase 1D(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50118478(CHEMBL3613749)
Affinity DataIC50: 6nMAssay Description:Inhibition of human Wip1 (2 to 420 residues) expressed in baculovirus-infected insect SF9 cells assessed as fluorescein diphosphate hydrolysis after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532279(CHEMBL4463696)
Affinity DataIC50: 7nMAssay Description:Inhibition of p38 MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532279(CHEMBL4463696)
Affinity DataIC50: 7nMAssay Description:Inhibition of p38 MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-4(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532282(CHEMBL4539512)
Affinity DataIC50: 50nMAssay Description:Displacement of GSK215 from full length PAD4 (unknown origin) after 50 mins by fluorescence polarization assay in absence of calciumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-4(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532282(CHEMBL4539512)
Affinity DataIC50: 50nMAssay Description:Displacement of GSK215 from full length PAD4 (unknown origin) after 50 mins by fluorescence polarization assay in absence of calciumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM36470(2-(4-(3,4-Dimethoxyphenylamino)-6-(quinolin-6-ylam...)
Affinity DataIC50: 270nMAssay Description:Inhibition of aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM36470(2-(4-(3,4-Dimethoxyphenylamino)-6-(quinolin-6-ylam...)
Affinity DataIC50: 270nMAssay Description:Inhibition of aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50379281(CHEMBL2011504)
Affinity DataKd:  930nMAssay Description:Binding affinity to human Bcl-xL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50379281(CHEMBL2011504)
Affinity DataKd:  930nMAssay Description:Binding affinity to human Bcl-xL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInterleukin-2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532281(CHEMBL4515387)
Affinity DataKd:  4.20E+3nMAssay Description:Binding affinity to human IL-2 measured over 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInterleukin-2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532281(CHEMBL4515387)
Affinity DataKd:  4.20E+3nMAssay Description:Binding affinity to human IL-2 measured over 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed