Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50047639
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  9.70E+3nMAssay Description:Activation of TREK1 (unknown origin) expressed in HEK293 cells assessed as increase in current density relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  3.60E+4nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180657(CHEMBL3819108)
Affinity DataEC50:  1.25E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180658(CHEMBL3818800)
Affinity DataEC50:  2.13E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180659(CHEMBL3818672)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of human TREK1 expressed in CHO cells assessed as increase in channel currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataEC50:  1.00E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM30705(SMR000058231 | CHEMBL744 | cid_5070 | MLS000069369...)
Affinity DataEC50:  1.39E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 4(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  2.70E+4nMAssay Description:Activation of TRAAK (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 10(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  3.00E+4nMAssay Description:Activation of TREK2 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Rat)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180660((3S)-BUTYLPHTHALIDE)
Affinity DataIC50: 60nMAssay Description:Inhibition of of rat TREK1 expressed in CHO cells assessed as reversible current depressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180662(CHEMBL3817944)
Affinity DataIC50: 71nMAssay Description:Inhibition of of TREK1 (unknown origin) expressed in whole COS7 cells assessed as reduction in channel currents in presence of 10 uM arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium two pore domain channel subfamily K member 2(Bovine)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50088383(CHEBI:2668 | Amlodipine | Norvasc)
Affinity DataIC50: 430nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium two pore domain channel subfamily K member 2(Bovine)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180663(CHEMBL1275655 | CHEBI:7572)
Affinity DataIC50: 750nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium two pore domain channel subfamily K member 2(Bovine)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM22988(Arachidonoyl ethanolamide | Arachidonoylethanolami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM79172(Fluphenthixol | SMR000875208 | cid_10140115 | 2-[4...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium two pore domain channel subfamily K member 2(Bovine)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50017702(cid_6365505 | 1-(bis(4-fluorophenyl)methyl)-4-cinn...)
Affinity DataIC50: 2.50E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50066430(CHEMBL28854 | 2-(4-Methyl-piperazin-1-yl)-5-(2,3,5...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reversible current depressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]pro...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50067133(CHEMBL631 | 1-[2-(2-Hydroxy-3-propylamino-propoxy)...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of of TASK1 (unknown origin) expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 10(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of of TREK2 (unknown origin) expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50067133(CHEMBL631 | 1-[2-(2-Hydroxy-3-propylamino-propoxy)...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of of human TREK1 expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium two pore domain channel subfamily K member 2(Bovine)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50101817(CHEBI:7565 | Adalat | Adalat Cc | Afeditab Cr | BA...)
Affinity DataIC50: 8.20E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50180661(Norfluoxetine)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in tsA201 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of of human TREK1 expressed in tsA201 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM22871(13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of of human TREK1 expressed in oocytes assessed as reversible current depressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 10(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of of TREK2 (unknown origin) expressed in oocytes assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50117271(CHEMBL558 | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethy...)
Affinity DataIC50: 9.73E+4nMAssay Description:Inhibition of of TASK1 (unknown origin) expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50117271(CHEMBL558 | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethy...)
Affinity DataIC50: 1.73E+5nMAssay Description:Inhibition of of human TREK1 expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50017662(CHEMBL79 | N-(2,6-dimethylphenyl)-N(2),N(2)-diethy...)
Affinity DataIC50: 2.07E+5nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed