Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 50046828
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50214969(Mangostin | alpha-mangostin | 1,3,6-Trihydroxy-7-m...)
Affinity DataKi:  2.85E+3nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50241453(gamma-mangostin | 1,3,6,7-tetrahydroxy-2,8-bis(3-m...)
Affinity DataKi:  3.17E+3nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataKi:  1.20E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50133593(CHEMBL3261712)
Affinity DataKi:  1.74E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed