Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50006389
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499493(CHEMBL3739648)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499492(CHEMBL3740684)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499501(CHEMBL3741934)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499502(CHEMBL3740237)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499491(CHEMBL3741668)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499504(CHEMBL3741412)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499508(CHEMBL3740363)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499492(CHEMBL3740684)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499495(CHEMBL3740645)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499488(CHEMBL3739741)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499494(CHEMBL3740130)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499489(CHEMBL3741681)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499489(CHEMBL3741681)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499506(CHEMBL3741276)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499505(CHEMBL3741076)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499505(CHEMBL3741076)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499488(CHEMBL3739741)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499512(CHEMBL3740213)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499496(CHEMBL3740255)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499511(CHEMBL3741820)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499510(CHEMBL3740434)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499499(CHEMBL3740061)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499498(CHEMBL3741816)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499503(CHEMBL3740867)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499506(CHEMBL3741276)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499497(CHEMBL3741010)
Affinity DataIC50: 92nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499507(CHEMBL3740075)
Affinity DataIC50: 104nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499502(CHEMBL3740237)
Affinity DataIC50: 107nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499500(CHEMBL3739670)
Affinity DataIC50: 3.80E+3nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 5(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P2X5R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P2X1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P2X2/3R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P2X4R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P2X3R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499509(CHEMBL3740635)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat P2X7R expressed in BzATP-stimulated HEK293 cells incubated for 20 mins followed by BzATP stimulation measured every 1 sec ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P2X2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499492(CHEMBL3740684)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499492(CHEMBL3740684)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499492(CHEMBL3740684)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499488(CHEMBL3739741)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499488(CHEMBL3739741)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499488(CHEMBL3739741)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed