Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50046805
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  220nMAssay Description:Competitive binding affinity to human ERBB2 in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131844(CHEMBL3633349)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131844(CHEMBL3633349)
Affinity DataKd:  310nMAssay Description:Binding affinity to wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  410nMAssay Description:Competitive binding affinity to human TXK in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  81nMAssay Description:Competitive binding affinity to human TTK in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  30nMAssay Description:Competitive binding affinity to human JAK3 in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  2.80E+3nMAssay Description:Competitive binding affinity to human JAK1 JH2 domain pseudokinase in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  140nMAssay Description:Competitive binding affinity to human ITK in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  430nMAssay Description:Competitive binding affinity to human GAK in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  130nMAssay Description:Competitive binding affinity to human ERBB4 in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  0.960nMAssay Description:Competitive binding affinity to human EGFR T790M mutant in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  220nMAssay Description:Competitive binding affinity to human wild type EGFR in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  290nMAssay Description:Competitive binding affinity to human BTK in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataKd:  320nMAssay Description:Competitive binding affinity to human BLK in presence of immobilized ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131840(CHEMBL3633142)
Affinity DataIC50: 50nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131839(CHEMBL3633141)
Affinity DataIC50: 348nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131841(CHEMBL3633143)
Affinity DataIC50: 386nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131842(CHEMBL3633151)
Affinity DataIC50: 521nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131843(CHEMBL3633152)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of wild type EGFR phosphorylation in human A431 cells after 60 mins by mesoscale multiplex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed