Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50047101
TargetAdenosine receptor A1(Rat)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50009552(CHA | CHEMBL45891 | N6-Cyclohexylado (CHA) | 2-[6-...)
Affinity DataKd:  1.30nMAssay Description:Displacement of [3H] CGS 21680 from rat hippocampus adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148598(Evodenoson | ATL-313 | DE-112)
Affinity DataKd:  0.700nMAssay Description:Displacement of 2-[2-(4-amino-3-[125I]iodophenyl)ethylamino]adenosine from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataEC50:  2.35E+4nMAssay Description:Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataEC50:  730nMAssay Description:Agonist activity at human adenosine A2A receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataEC50:  310nMAssay Description:Agonist activity at human adenosine A1 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148579(CHEMBL3770836)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148579(CHEMBL3770836)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148578(CHEMBL3770730)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM25474(N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148578(CHEMBL3770730)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetTransmembrane domain-containing protein TMIGD3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50118803((2R,3R,4S,5S)-3,4-dihydroxy-2-[6-(3-iodo-benzylami...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at adenosine A3 receptor in human NPE cells assessed as inhibition of adenosine-triggered cell shrinkageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM25474(N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 56nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148577(CHEMBL1994526)
Affinity DataIC50: 140nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148577(CHEMBL1994526)
Affinity DataIC50: 200nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 320nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50117215(5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]tri...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [125I]I-AB-MECA from recombinant human adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM97464(US8609833, 17 | US8470800, A | US8609833, 86)
Affinity DataKi:  0.970nMAssay Description:Binding affinity to adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor by scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to adenosine A3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50118810(CHEMBL139000 | N6-[(R)-1-Methyl-2-phenylethyl]ado ...)
Affinity DataKi:  2nMAssay Description:Binding affinity to adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148580(CHEMBL3770601)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-PIA from human recombinant adenosine A1 receptor after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50118810(CHEMBL139000 | N6-[(R)-1-Methyl-2-phenylethyl]ado ...)
Affinity DataKi:  16nMAssay Description:Binding affinity to adenosine A3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetTransmembrane domain-containing protein TMIGD3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50074225(6-Ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propyl-...)
Affinity DataKi:  19nMAssay Description:Antagonist activity at adenosine A3 receptor in human NPE cells assessed as inhibition of adenosine-triggered cell shrinkageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148580(CHEMBL3770601)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]CGS21680 from human recombinant adenosine 2A receptor after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148580(CHEMBL3770601)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]I-AB-MECA from recombinant human adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM35804(3-(4-{2-[6-Amino-9-((2R,3R,4S,5S)-5-ethylcarbamoyl...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CGS21680 from human recombinant adenosine 2A receptor after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransmembrane domain-containing protein TMIGD3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148601(CHEMBL3771367)
Affinity DataKi:  31nMAssay Description:Displacement of [125I]AB-MECA from human brain adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50453216(CHEMBL2113496 | 2-(l-hexyn-l-yl)adenosine (8, YT-1...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-CGS2168 from human recombinant adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148599(CHEMBL3770782)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-CGS2168 from human recombinant adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataKi:  51nMAssay Description:Binding affinity to adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM35804(3-(4-{2-[6-Amino-9-((2R,3R,4S,5S)-5-ethylcarbamoyl...)
Affinity DataKi:  67nMAssay Description:Displacement of [125I]I-AB-MECA from recombinant human adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetTransmembrane domain-containing protein TMIGD3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148600(CHEMBL3770003)
Affinity DataKi:  108nMAssay Description:Displacement of [125I]AB-MECA from human brain adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148580(CHEMBL3770601)
Affinity DataKi:  140nMAssay Description:Agonist activity at recombinant human adenosine A2B receptor assessed as cAMP accumulation preincubated for 45 mins followed by forskolin addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50148602(CHEMBL3770194)
Affinity DataKi:  910nMAssay Description:Antagonist activity at human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed