Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50046575
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119612(CHEMBL3618236)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119611(CHEMBL3618235)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119613(CHEMBL3618237)
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119612(CHEMBL3618236)
Affinity DataIC50: 18nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119619(CHEMBL3618243)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119615(CHEMBL3618239)
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119617(CHEMBL3618241)
Affinity DataIC50: 26nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119613(CHEMBL3618237)
Affinity DataIC50: 32nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119618(CHEMBL3618242)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119618(CHEMBL3618242)
Affinity DataIC50: 34nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119620(CHEMBL3618244)
Affinity DataIC50: 36nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119606(CHEMBL3618231)
Affinity DataIC50: 37nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119606(CHEMBL3618231)
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119614(CHEMBL3618238)
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119620(CHEMBL3618244)
Affinity DataIC50: 45nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119608(CHEMBL3618232)
Affinity DataIC50: 57nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119614(CHEMBL3618238)
Affinity DataIC50: 62nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119615(CHEMBL3618239)
Affinity DataIC50: 69nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119609(CHEMBL3618233)
Affinity DataIC50: 86nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119617(CHEMBL3618241)
Affinity DataIC50: 121nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119619(CHEMBL3618243)
Affinity DataIC50: 157nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119609(CHEMBL3618233)
Affinity DataIC50: 198nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataIC50: 206nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119608(CHEMBL3618232)
Affinity DataIC50: 229nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119610(CHEMBL3618234)
Affinity DataIC50: 277nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119616(CHEMBL3618240)
Affinity DataIC50: 294nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119616(CHEMBL3618240)
Affinity DataIC50: 412nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119610(CHEMBL3618234)
Affinity DataIC50: 780nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  0.600nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  5.30nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119613(CHEMBL3618237)
Affinity DataKi:  5.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119614(CHEMBL3618238)
Affinity DataKi:  5.70nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119619(CHEMBL3618243)
Affinity DataKi:  6.10nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119617(CHEMBL3618241)
Affinity DataKi:  6.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119616(CHEMBL3618240)
Affinity DataKi:  6.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119618(CHEMBL3618242)
Affinity DataKi:  8.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  11nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119609(CHEMBL3618233)
Affinity DataKi:  14nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119621(CHEMBL3618245)
Affinity DataKi:  17nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119620(CHEMBL3618244)
Affinity DataKi:  26nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119606(CHEMBL3618231)
Affinity DataKi:  29nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119612(CHEMBL3618236)
Affinity DataKi:  43nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119615(CHEMBL3618239)
Affinity DataKi:  43nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119611(CHEMBL3618235)
Affinity DataKi:  54nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119608(CHEMBL3618232)
Affinity DataKi:  148nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119610(CHEMBL3618234)
Affinity DataKi:  529nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed