Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50046641
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203487(US9221809, 24)
Affinity DataIC50: 11nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203488(US9221809, 25)
Affinity DataIC50: 18nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203526(US9221809, 83)
Affinity DataIC50: 19nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203466(US9221809, 3)
Affinity DataIC50: 25nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203492(US9221809, 65 | US9221809, 29)
Affinity DataIC50: 27nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203530(US9221809, 87)
Affinity DataIC50: 36nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203489(US9221809, 26)
Affinity DataIC50: 43nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203491(US9221809, 28)
Affinity DataIC50: 43nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203494(US9221809, 31)
Affinity DataIC50: 67nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203488(US9221809, 25)
Affinity DataIC50: 78nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203547(US9221809, 104)
Affinity DataIC50: 79nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203548(US9221809, 105)
Affinity DataIC50: 85nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203567(US9221809, 124)
Affinity DataIC50: 93nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203513(US9221809, 50)
Affinity DataIC50: 100nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203531(US9221809, 88)
Affinity DataIC50: 121nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203490(US9221809, 27)
Affinity DataIC50: 135nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203492(US9221809, 65 | US9221809, 29)
Affinity DataIC50: 141nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203526(US9221809, 83)
Affinity DataIC50: 187nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203533(US9221809, 90)
Affinity DataIC50: 258nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203494(US9221809, 31)
Affinity DataIC50: 292nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203548(US9221809, 105)
Affinity DataIC50: 333nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203523(US9221809, 60)
Affinity DataIC50: 352nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203538(US9221809, 95)
Affinity DataIC50: 354nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203487(US9221809, 24)
Affinity DataIC50: 375nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203532(US9221809, 89)
Affinity DataIC50: 450nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203551(US9221809, 108)
Affinity DataIC50: 454nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122948(CHEMBL3622531)
Affinity DataIC50: 470nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203493(US9221809, 30)
Affinity DataIC50: 490nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203566(US9221809, 123)
Affinity DataIC50: 565nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203567(US9221809, 124)
Affinity DataIC50: 580nMAssay Description:Inhibition of IRAK4-mediated NFkappaB activation in human THP1-XBlue cells assessed as LPS-induced secreted embryonic alkaline phosphatase activity t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203529(US9221809, 86)
Affinity DataIC50: 620nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203525(US9221809, 62)
Affinity DataIC50: 635nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203524(US9221809, 61)
Affinity DataIC50: 972nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203470(US9221809, 7)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203478(US9221809, 15)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203526(US9221809, 83)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction of IL1beta-induced TNFalpha production treated 30 mins before IL1beta stimulation measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203534(US9221809, 91)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of IRAK4 (unknown origin) using 5FAM-RKRQGSVRRRVHCCOOH as substrate after 30 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM203526(US9221809, 83)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction of TLR 7/8 agonist R848-induced TNFalpha production treated 30 mins before R848 stimulation m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)