Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50046510
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116565(CHEMBL3608943)
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116566(CHEMBL3608942)
Affinity DataIC50: 107nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116567(CHEMBL3608316)
Affinity DataIC50: 113nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116568(CHEMBL3608941)
Affinity DataIC50: 132nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116528(CHEMBL3608946)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116573(CHEMBL3609822)
Affinity DataIC50: 149nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116568(CHEMBL3608941)
Affinity DataIC50: 156nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116571(CHEMBL3609824)
Affinity DataIC50: 173nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 181nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116525(CHEMBL3609818)
Affinity DataIC50: 184nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116571(CHEMBL3609824)
Affinity DataIC50: 193nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 202nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116572(CHEMBL3609823)
Affinity DataIC50: 207nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116528(CHEMBL3608946)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116524(CHEMBL3608947)
Affinity DataIC50: 217nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116523(CHEMBL3609820)
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116524(CHEMBL3608947)
Affinity DataIC50: 225nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116567(CHEMBL3608316)
Affinity DataIC50: 225nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116569(CHEMBL3608940)
Affinity DataIC50: 318nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116573(CHEMBL3609822)
Affinity DataIC50: 347nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116526(CHEMBL3608945)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116526(CHEMBL3608945)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116564(CHEMBL3608944)
Affinity DataIC50: 361nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 387nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116527(CHEMBL3609817)
Affinity DataIC50: 398nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 400nMAssay Description:Inhibition of human ERG expressed in HEK cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116569(CHEMBL3608940)
Affinity DataIC50: 403nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116527(CHEMBL3609817)
Affinity DataIC50: 424nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116565(CHEMBL3608943)
Affinity DataIC50: 426nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116572(CHEMBL3609823)
Affinity DataIC50: 434nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116525(CHEMBL3609818)
Affinity DataIC50: 455nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116566(CHEMBL3608942)
Affinity DataIC50: 504nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116570(CHEMBL3609825)
Affinity DataIC50: 557nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116570(CHEMBL3609825)
Affinity DataIC50: 588nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116524(CHEMBL3608947)
Affinity DataIC50: 648nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116524(CHEMBL3608947)
Affinity DataIC50: 648nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116526(CHEMBL3608945)
Affinity DataIC50: 699nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116526(CHEMBL3608945)
Affinity DataIC50: 699nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116564(CHEMBL3608944)
Affinity DataIC50: 748nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERG expressed in HEK cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextromethorphan-O demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116522(CHEMBL3609821)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116523(CHEMBL3609820)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116522(CHEMBL3609821)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in diclofenac 4'-hydroxylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Affinity DataIC50: 3.40E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation incubated for 60 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.40E+5nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation incubated for 60 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)