Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50006303
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498590(CHEMBL3609637)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498583(CHEMBL3609639)
Affinity DataIC50: 10nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498578(CHEMBL3609635)
Affinity DataIC50: 30nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498590(CHEMBL3609637)
Affinity DataIC50: 30nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498590(CHEMBL3609637)
Affinity DataIC50: 32nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498582(CHEMBL3609636)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498588(CHEMBL3609633)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498580(CHEMBL3609638)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498583(CHEMBL3609639)
Affinity DataIC50: 50nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498589(CHEMBL3609634)
Affinity DataIC50: 60nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498592(CHEMBL3609642)
Affinity DataIC50: 70nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498581(CHEMBL3609626)
Affinity DataIC50: 70nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498578(CHEMBL3609635)
Affinity DataIC50: 70nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498590(CHEMBL3609637)
Affinity DataIC50: 130nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498594(CHEMBL3609625)
Affinity DataIC50: 150nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498580(CHEMBL3609638)
Affinity DataIC50: 150nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498591(CHEMBL3609640)
Affinity DataIC50: 150nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498588(CHEMBL3609633)
Affinity DataIC50: 170nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498584(CHEMBL3609641)
Affinity DataIC50: 180nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498582(CHEMBL3609636)
Affinity DataIC50: 190nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498579(CHEMBL3609628)
Affinity DataIC50: 240nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498589(CHEMBL3609634)
Affinity DataIC50: 240nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498581(CHEMBL3609626)
Affinity DataIC50: 320nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498593(CHEMBL3609627)
Affinity DataIC50: 370nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498596(CHEMBL3609622)
Affinity DataIC50: 390nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498595(CHEMBL3609623)
Affinity DataIC50: 430nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498597(CHEMBL3609624)
Affinity DataIC50: 440nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498592(CHEMBL3609642)
Affinity DataIC50: 470nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498583(CHEMBL3609639)
Affinity DataIC50: 530nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498598(CHEMBL3608322)
Affinity DataIC50: 580nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498594(CHEMBL3609625)
Affinity DataIC50: 700nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498599(CHEMBL3609631)
Affinity DataIC50: 880nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498578(CHEMBL3609635)
Affinity DataIC50: 900nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498591(CHEMBL3609640)
Affinity DataIC50: 940nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498579(CHEMBL3609628)
Affinity DataIC50: 1.01E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498587(CHEMBL3609629)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498585(CHEMBL3609630)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498586(CHEMBL3609632)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498584(CHEMBL3609641)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498593(CHEMBL3609627)
Affinity DataIC50: 1.58E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498580(CHEMBL3609638)
Affinity DataIC50: 1.83E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498579(CHEMBL3609628)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498590(CHEMBL3609637)
Affinity DataIC50: 2.61E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498582(CHEMBL3609636)
Affinity DataIC50: 2.68E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498595(CHEMBL3609623)
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498597(CHEMBL3609624)
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498597(CHEMBL3609624)
Affinity DataIC50: 3.22E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498581(CHEMBL3609626)
Affinity DataIC50: 3.56E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498593(CHEMBL3609627)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498595(CHEMBL3609623)
Affinity DataIC50: 4.06E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
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