Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 6804
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152730(7-Amino-N-hydroxypentanamide (6))
Affinity DataIC50: 68nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152729(6-Amino-N-hydroxypentanamide (5))
Affinity DataIC50: 130nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152731(8-Amino-N-hydroxypentanamide (7))
Affinity DataIC50: 150nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
University of Pennsylvania

LigandPNGBDBM152728(5-Amino-N-hydroxypentanamide (4))
Affinity DataIC50: 170nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 250 nM APAH (∼50% Zn2+ occupancy), 150 μM substrate, and 0−250 μM inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152725((3-azaniumylpropyl)(7,7,7-trifluoro-6-oxoheptyl)az...)
Affinity DataIC50: 260nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152731(8-Amino-N-hydroxypentanamide (7))
Affinity DataIC50: 2.20E+3nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152730(7-Amino-N-hydroxypentanamide (6))
Affinity DataIC50: 5.30E+3nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152726((3-azaniumylpropyl)(5-sulfanylpentyl)azanium (2))
Affinity DataIC50: 1.20E+4nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152727((3-azaniumylpropyl)[5-(hydroxycarbamoyl)pentyl]aza...)
Affinity DataIC50: 1.40E+4nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152729(6-Amino-N-hydroxypentanamide (5))
Affinity DataIC50: 1.90E+4nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

LigandPNGBDBM152728(5-Amino-N-hydroxypentanamide (4))
Affinity DataIC50: 1.20E+5nMpH: 8.2Assay Description:Activity assays were conducted at 25 °C and contained 500 nM HDAC8 enzyme, 150 μM Ac-Arg-His-Lys(Ac)-Lys(Ac)-aminomethylcoumarin substrate (BML-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2015
Entry Details Article
PubMed