Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50046060
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: 185nMAssay Description:Inhibition of PI3Kgamma in human THP1 cells assessed as inhibition of MCP1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PI3Kbeta in human THP1 cells assessed as inhibition of CSF1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PI3Kalpha in human THP1 cells assessed as inhibition of CSF1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as inhibition of CSF1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093355(CHEMBL3586677)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093356(CHEMBL3586676)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093354(CHEMBL3586679)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093395(CHEMBL3586674)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093417(CHEMBL3586672)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093437(CHEMBL3586668)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093399(CHEMBL3586673)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093434(CHEMBL3586670)
Affinity DataKi:  0.0170nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50093436(CHEMBL3586669)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093353(CHEMBL3586680)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093391(CHEMBL3586675)
Affinity DataKi:  0.0340nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093439(CHEMBL3586666)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50093419(CHEMBL3586671)
Affinity DataKi:  0.0660nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093440(CHEMBL3586665)
Affinity DataKi:  0.157nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandPNGBDBM50093438(CHEMBL3586667)
Affinity DataKi:  0.330nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of DNAPK (unknown origin) using ATP and PPLSQEAFADLWKKK substrate by radiometric peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of JAK2 (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDR (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRC (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRC (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of c-KIT (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of c-KIT (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDR (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) using ATP and GSM peptide substrate by radiometric peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) using ATP and GSM peptide substrate by radiometric peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of DNAPK (unknown origin) using ATP and PPLSQEAFADLWKKK substrate by radiometric peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed