Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50046121
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095537(CHEMBL3590526 | US9598381, 1a (S enantiomer))
Affinity DataIC50: 2.80nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095536(CHEMBL3590527 | US9598381, 1 (racemate))
Affinity DataIC50: 5.60nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) using p53 (361 to 380) as substrate assessed as incorporation of tritium labeled methyl group from [3H]-SAM to p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50396022(CHEMBL2169920)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant full-length human SMYD2 (1 to 433) expressed in Escherichia coli BL21Star(DE3) cells using p53 peptide as substrate after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50396022(CHEMBL2169920)
Affinity DataIC50: 230nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095634(CHEMBL3590519 | US9598381, 11)
Affinity DataIC50: 440nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095615(CHEMBL3590524 | US9598381, 13)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095633(CHEMBL3590520 | US9598381, 3)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095612(CHEMBL3590525 | US9598381, 5)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095635(CHEMBL3590518 | US9598381, 2)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095625(CHEMBL3590523 | US9598381, 6)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50095632(CHEMBL3590521 | US9598381, 14)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed