Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50045985
TargetHistone deacetylase 6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 149nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 255nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 371nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataKi:  250nMAssay Description:Binding affinity to human Zn2+-HDAC8 assessed as loss of activity by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataKi:  7.00E+3nMAssay Description:Reversible-time dependent inhibition of human wild type HDAC8 by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed