Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50046877
TargetDihydrofolate reductase(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of rat DHFR extracted from liver using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50: 4nMAssay Description:Inhibition of DHFR in mouse L1210 cells using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of DHFR in Lactobacillus casei using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluoromet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50079754(N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-N*3*-methy...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at PAR1 in human platelet membranes assessed as inhibition of interaction of PAR1 with [Ala-Phe(p-F)-Arg-Cha-HArg-Tyr-NH2] by Chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50079751(N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-7H-pyrrolo...)
Affinity DataIC50: 56nMAssay Description:Antagonist activity at PAR1 in human platelet membranes assessed as inhibition of interaction of PAR1 with [Ala-Phe(p-F)-Arg-Cha-HArg-Tyr-NH2] by Chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50079756(7-(4-Isopropyl-benzyl)-7H-pyrrolo[3,2-f]quinazolin...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at PAR1 (unknown origin) assessed as inhibition of thrombin-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50049905(TCMDC-137283 | 7-(1-Ethyl-propyl)-8-methyl-7H-pyrr...)
Affinity DataKi:  0nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Yeast)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50049905(TCMDC-137283 | 7-(1-Ethyl-propyl)-8-methyl-7H-pyrr...)
Affinity DataKi:  0.0300nMAssay Description:Competitive inhibition of Candida albicans DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50049904(7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | TCMDC-1...)
Affinity DataKi:  1nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed