Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50045621
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataIC50: 7nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071328(CHEMBL3410213)
Affinity DataIC50: 9nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071375(CHEMBL3410223 | US10618900, No. CTEP)
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071332(CHEMBL3410214)
Affinity DataIC50: 11nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071369(CHEMBL3410220)
Affinity DataIC50: 12nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071333(CHEMBL3410215)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071376(CHEMBL3410224)
Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071322(CHEMBL3410209)
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071372(CHEMBL1946770)
Affinity DataIC50: 28nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071334(CHEMBL3410216)
Affinity DataIC50: 28nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071335(CHEMBL3410217)
Affinity DataIC50: 70nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071371(CHEMBL3410221)
Affinity DataIC50: 97nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071367(CHEMBL3410218)
Affinity DataIC50: 100nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071326(CHEMBL3410211)
Affinity DataIC50: 124nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071368(CHEMBL3410219)
Affinity DataIC50: 141nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071324(CHEMBL3410207)
Affinity DataIC50: 161nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071377(CHEMBL3407528)
Affinity DataIC50: 295nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071327(CHEMBL3410212)
Affinity DataIC50: 387nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071378(CHEMBL3410225)
Affinity DataIC50: 488nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071373(CHEMBL3410222)
Affinity DataIC50: 872nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071324(CHEMBL3410207)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071375(CHEMBL3410223 | US10618900, No. CTEP)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071376(CHEMBL3410224)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071323(CHEMBL3410208)
Affinity DataIC50: 2.50E+3nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071325(CHEMBL3410210)
Affinity DataIC50: 5.60E+3nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071372(CHEMBL1946770)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071369(CHEMBL3410220)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071328(CHEMBL3410213)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071375(CHEMBL3410223 | US10618900, No. CTEP)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071372(CHEMBL1946770)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071333(CHEMBL3410215)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071332(CHEMBL3410214)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071371(CHEMBL3410221)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071376(CHEMBL3410224)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071324(CHEMBL3410207)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071322(CHEMBL3410209)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071335(CHEMBL3410217)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071334(CHEMBL3410216)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071326(CHEMBL3410211)
Affinity DataKi:  213nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071367(CHEMBL3410218)
Affinity DataKi:  252nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071327(CHEMBL3410212)
Affinity DataKi:  255nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071377(CHEMBL3407528)
Affinity DataKi:  368nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071378(CHEMBL3410225)
Affinity DataKi:  559nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071368(CHEMBL3410219)
Affinity DataKi:  567nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071373(CHEMBL3410222)
Affinity DataKi:  1.44E+3nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071323(CHEMBL3410208)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071325(CHEMBL3410210)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed