Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 50044736
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50: 14nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028036(CHEMBL3338840)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028030(CHEMBL3338842)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 21nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50: 32nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 35nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 36nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028036(CHEMBL3338840)
Affinity DataIC50: 39nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028030(CHEMBL3338842)
Affinity DataIC50: 52nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 93nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 99nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028031(CHEMBL3338843)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028029(CHEMBL3338841)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028029(CHEMBL3338841)
Affinity DataIC50: 141nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 141nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028031(CHEMBL3338843)
Affinity DataIC50: 233nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028032(CHEMBL3338844)
Affinity DataIC50: 432nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 507nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50: 547nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50: 660nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50: 742nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 785nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028029(CHEMBL3338841)
Affinity DataIC50: 920nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028030(CHEMBL3338842)
Affinity DataIC50: 951nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028035(CHEMBL3338839)
Affinity DataIC50: 974nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028036(CHEMBL3338840)
Affinity DataIC50: 990nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028036(CHEMBL3338840)
Affinity DataIC50: 995nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028034(CHEMBL3338838)
Affinity DataIC50: 995nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028029(CHEMBL3338841)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028030(CHEMBL3338842)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50028031(CHEMBL3338843)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
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