Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50032959
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336923((R)-(5-chloro-6-(4-chlorophenylamino)pyridin-3-yl)...)
Affinity DataIC50: 64nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336924(3-chloro-N-(6-methylpyridin-3-yl)-5-(1-propyl-1H-b...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336926(3-chloro-5-(1-isobutyl-1H-benzo[d]imidazol-2-yl)-N...)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336925(3-chloro-5-(1-ethyl-1H-benzo[d]imidazol-2-yl)-N-(6...)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336927(3-chloro-5-(6-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336928(3-chloro-N-(4-chlorophenyl)-5-(1-propyl-1H-benzo[d...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336915(3-chloro-5-(4-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336916(3-chloro-N-(4-chlorophenyl)-5-(4-methyl-1-propyl-1...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336917(3-chloro-N-(4-chlorophenyl)-5-(4,5-dimethyl-1-prop...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336918(5-(1-butyl-1H-benzo[d]imidazol-2-yl)-3-chloro-N-(6...)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336922(3-chloro-5-(5-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336919(3-chloro-N-(4-chlorophenyl)-5-(5,6,7,8-tetrahydroi...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336920(3-chloro-N-(4-chlorophenyl)-5-(1,4-dimethyl-1H-imi...)
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]ABP688 from human recombinant mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336921(3-chloro-5-(7-chloro-1-propyl-1H-benzo[d]imidazol-...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]ABP688 from mGlu5 receptor in rat brain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed