Compile Data Set for Download or QSAR
Report error Found 380 Enz. Inhib. hit(s) with all data for entry = 50044465
TargetAlpha-1A adrenergic receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM69602(WB-4101 hydrochloride | N-(2,3-dihydro-1,4-benzodi...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM82247(SCH 23390,R(+) | CAS_87134-87-0 | CHEMBL2158641 | ...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human recombinant 5-HT1A receptor assessed as inhibition of 8-OH-DPAT-induced response by cellular dielectric spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant at D2S receptor assessed as inhibition of dopamine-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50060417(CHEMBL297784 | SB 206553 | SB-206553 | 5-Methyl-3,...)
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at human recombinant 5-HT2C receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant 5-HT6 receptor assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50026636(RAUWOLSCINE HYDROCHLORIDE | 17alpha-hydroxy-20alph...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human recombinant alpha2C adrenoceptor assessed as inhibition of epinephrine-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50117930(N-(4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidi...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(4) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 168nMAssay Description:Antagonist activity at human recombinant at D4 receptor assessed as inhibition of dopamine-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018019(CHEMBL3290012)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]imipramine from human recombinant SERT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50018019(CHEMBL3290012)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]methylspiperone from human recombinant D2S receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]methylspiperone from human recombinant D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM82247(SCH 23390,R(+) | CAS_87134-87-0 | CHEMBL2158641 | ...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018051(CHEMBL3289972)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018250(CHEMBL3290016)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018239(CHEMBL3290004)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018022(CHEMBL3289944)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018019(CHEMBL3290012)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018224(CHEMBL3290002)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM85098(N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-y...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018203(CHEMBL3289991)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018231(CHEMBL3290003)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018243(CHEMBL3290008)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018019(CHEMBL3290012)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018049(CHEMBL3289970)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018250(CHEMBL3290016)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018251(CHEMBL3290017)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018190(CHEMBL3289978)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018223(CHEMBL3290001)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018019(CHEMBL3290012)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018190(CHEMBL3289978)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018231(CHEMBL3290003)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018240(CHEMBL3290005)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018248(CHEMBL3290014)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Adamed

Curated by ChEMBL
LigandPNGBDBM50018208(CHEMBL3289995)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
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