Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50043340
TargetFocal adhesion kinase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50439561(CHEMBL1965660 | US9670191, F26)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 32nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM33971(Sotrastaurin | AEB071 | med.21724, Compound 190)
Affinity DataIC50: 50nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50396934(CHEMBL2170804 | CHEMBL2001019 | US9062045, Compara...)
Affinity DataIC50: 50nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 50nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 63nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50: 100nMAssay Description:Inhibition of MAPKAPK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataIC50: 100nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50: 501nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50439560(CHEMBL1967252)
Affinity DataIC50: 631nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 794nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 794nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed