Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50005531
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 3nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM14948(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM14948(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50: 39nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 51nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 196nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 240nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 348nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed