Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50005433
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataKd:  0.140nMAssay Description:Binding affinity to JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102557(US8536172, I-6)
Affinity DataIC50: 3nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataIC50: 3nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102560(US8536172, I-9)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50: 6nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492029(CHEMBL2390974)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492032(CHEMBL2392831)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102564(US8536172, I-13)
Affinity DataIC50: 7nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102571(US8536172, I-20)
Affinity DataIC50: 7nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102569(US8536172, I-18)
Affinity DataIC50: 8nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102562(US8536172, I-11)
Affinity DataIC50: 10nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102604(US8536172, I-53)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102568(US8536172, I-17)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492031(CHEMBL2392839)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50: 17nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataIC50: 20nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102557(US8536172, I-6)
Affinity DataIC50: 24nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492029(CHEMBL2390974)
Affinity DataIC50: 24nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102616(US8536172, I-65)
Affinity DataIC50: 27nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102554(US8536172, I-3)
Affinity DataIC50: 29nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102569(US8536172, I-18)
Affinity DataIC50: 33nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492032(CHEMBL2392831)
Affinity DataIC50: 35nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102560(US8536172, I-9)
Affinity DataIC50: 36nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102571(US8536172, I-20)
Affinity DataIC50: 40nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492033(CHEMBL2392830)
Affinity DataIC50: 44nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102564(US8536172, I-13)
Affinity DataIC50: 49nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102568(US8536172, I-17)
Affinity DataIC50: 66nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102562(US8536172, I-11)
Affinity DataIC50: 68nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492031(CHEMBL2392839)
Affinity DataIC50: 86nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492030(CHEMBL2392829)
Affinity DataIC50: 94nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492032(CHEMBL2392831)
Affinity DataIC50: 104nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102554(US8536172, I-3)
Affinity DataIC50: 180nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102560(US8536172, I-9)
Affinity DataIC50: 200nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102604(US8536172, I-53)
Affinity DataIC50: 220nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataIC50: 240nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492033(CHEMBL2392830)
Affinity DataIC50: 280nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50: 290nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492031(CHEMBL2392839)
Affinity DataIC50: 420nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102569(US8536172, I-18)
Affinity DataIC50: 650nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492030(CHEMBL2392829)
Affinity DataIC50: 650nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102564(US8536172, I-13)
Affinity DataIC50: 700nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102557(US8536172, I-6)
Affinity DataIC50: 710nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102562(US8536172, I-11)
Affinity DataIC50: 820nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50492029(CHEMBL2390974)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102568(US8536172, I-17)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102571(US8536172, I-20)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102616(US8536172, I-65)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed