Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50042865
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 17nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432375(CHEMBL2348416)
Affinity DataIC50: 18nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50: 23nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 24nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432377(CHEMBL2348414)
Affinity DataIC50: 29nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432374(CHEMBL2348418)
Affinity DataIC50: 30nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 36nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432377(CHEMBL2348414)
Affinity DataIC50: 38nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432375(CHEMBL2348416)
Affinity DataIC50: 44nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432374(CHEMBL2348418)
Affinity DataIC50: 47nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432376(CHEMBL2348415)
Affinity DataIC50: 65nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432376(CHEMBL2348415)
Affinity DataIC50: 75nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432378(CHEMBL2348419)
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged HER2 cytoplasmic domain (676 to 1255) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432378(CHEMBL2348419)
Affinity DataIC50: 110nMAssay Description:Inhibition of human N-terminal DYKDDDD-tagged EGFR cytoplasmic domain (669 to 1210) expressed in baculovirus expression system incubated for 5 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 230nMAssay Description:Inhibition of wild type N-terminal FLAG-tagged B-raf (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 240nMAssay Description:Inhibition of HER4 cytoplasmic domain (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-32P]ATP additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 870nMAssay Description:Inhibition of N-terminal FLAG-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged p38alpha (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of LYNB (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of LCK (unknown origin) incubated for 5 mins prior to ATP addition measured after 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of c-MET (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of LYNA (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TIE2 (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-kit (unknown origin) incubated for 5 mins prior to ATP addition measured after 20 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-fused MEK1 (unknown origin) incubated for 5 mins prior to [gamma-33P]ATP addition measured after 20 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged PLK (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His6x-tagged aurora-B (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged full length FAK (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged JNK1 (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged IKKbeta (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged GSK3beta (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged ERK1 (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of InsR (unknown origin) incubated for 5 mins prior to ATP addition measured after 60 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) incubated for 5 mins prior to ATP addition measured after 20 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged full length BMX (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group C member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged TAK1 (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged TTK (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbeta (unknown origin) incubated for 5 mins prior to ATP addition measured after 60 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) incubated for 5 mins prior to ATP addition measured after 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged VEGFR2 cytoplasmic domain (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR1 (unknown origin) incubated for 5 mins prior to ATP addition measured after 5 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged MEKK (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CSK (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged full length FAK (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to ATP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) incubated for 5 mins prior to ATP addition measured after 10 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed