Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50042824
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataIC50: 0.400nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 416 amino acid residues) using [3H]-SAM assessed as inhibition of nucleosome methylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50: 77nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant full length human NNMT measured for 30 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)
Affinity DataIC50: 1.82E+4nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  38nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50396981(CHEMBL2171174)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant full length human NNMT measured for 30 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  950nMAssay Description:Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed