Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 8412
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 2.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 3.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246600(DNA topoisomerase inhibitor, 2)
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246599(DNA topoisomerase inhibitor, 1)
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246600(DNA topoisomerase inhibitor, 2)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246599(DNA topoisomerase inhibitor, 1)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246604(DNA topoisomerase inhibitor, 6)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246603(DNA topoisomerase inhibitor, 5)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246602(DNA topoisomerase inhibitor, 4)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246601(DNA topoisomerase inhibitor, 3)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246601(DNA topoisomerase inhibitor, 3)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246602(DNA topoisomerase inhibitor, 4)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246603(DNA topoisomerase inhibitor, 5)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246604(DNA topoisomerase inhibitor, 6)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246605(DNA topoisomerase inhibitor, 7)
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246606(DNA topoisomerase inhibitor, 8)
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246605(DNA topoisomerase inhibitor, 7)
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246606(DNA topoisomerase inhibitor, 8)
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed