Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50005245
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489341(CHEMBL2314617)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489349(CHEMBL2314606)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489349(CHEMBL2314606)
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393452(CHEMBL2159511)
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489349(CHEMBL2314606)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393452(CHEMBL2159511)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489338(CHEMBL2314613)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489342(CHEMBL2314603)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489342(CHEMBL2314603)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489342(CHEMBL2314603)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393453(CHEMBL2159510)
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489347(CHEMBL2314602)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489353(CHEMBL2314609)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489341(CHEMBL2314617)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489351(CHEMBL2314604)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489341(CHEMBL2314617)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393453(CHEMBL2159510)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489345(CHEMBL2314618)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393452(CHEMBL2159511)
Affinity DataIC50: 4nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489346(CHEMBL2314601)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489344(CHEMBL2314608)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489348(CHEMBL2314605)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489347(CHEMBL2314602)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489346(CHEMBL2314601)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489339(CHEMBL2314610)
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393453(CHEMBL2159510)
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489343(CHEMBL2314607)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489339(CHEMBL2314610)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489343(CHEMBL2314607)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489344(CHEMBL2314608)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393454(CHEMBL2159509)
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489350(CHEMBL2314616)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489347(CHEMBL2314602)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489339(CHEMBL2314610)
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489345(CHEMBL2314618)
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489344(CHEMBL2314608)
Affinity DataIC50: 13nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489346(CHEMBL2314601)
Affinity DataIC50: 13nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489338(CHEMBL2314613)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489345(CHEMBL2314618)
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489351(CHEMBL2314604)
Affinity DataIC50: 22nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489343(CHEMBL2314607)
Affinity DataIC50: 22nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489350(CHEMBL2314616)
Affinity DataIC50: 25nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489338(CHEMBL2314613)
Affinity DataIC50: 31nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489345(CHEMBL2314618)
Affinity DataIC50: 31nMAssay Description:Inhibition of gamma secretase-mediated notch cleavage in HEK293 cells expressing human notch protein with truncated extracellular EGF repeat domain b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489351(CHEMBL2314604)
Affinity DataIC50: 38nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489350(CHEMBL2314616)
Affinity DataIC50: 66nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489340(CHEMBL2314612)
Affinity DataIC50: 120nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489354(CHEMBL2314611)
Affinity DataIC50: 250nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
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