Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50040677
TargetSerine/threonine-protein kinase pim-2(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  130nMAssay Description:Competitive binding affinity to PIM2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  50nMAssay Description:Competitive binding affinity to PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 7nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50398243(CHEMBL2177299)
Affinity DataIC50: 20nMAssay Description:Competitive inhibition of PIM1 using KKRNRTLTV as substrate after 5 mins by scintillation counter in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 34nMAssay Description:Inhibition of haspinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 40nMAssay Description:Competitive inhibition of PIM2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 44nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataIC50: 50nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 57nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50398243(CHEMBL2177299)
Affinity DataIC50: 63nMAssay Description:Competitive inhibition of CK2alpha using RRREDEESDDEE as substrate after 5 mins by scintillation counter in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 69nMAssay Description:Competitive inhibition of PIM3 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 363nMAssay Description:Competitive inhibition of PIM2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 1.10E+3nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-1(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26626((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Cylene Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26626((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Affinity DataKi:  100nMAssay Description:Competitive inhibition of PIM2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed