Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50040584
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50: 2nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of C-Raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 22nMAssay Description:Inhibition of B-Raf in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 46nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 48nMAssay Description:Inhibition of C-Raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 100nMAssay Description:Inhibition of B-Raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 160nMAssay Description:Inhibition of B-Raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 290nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataKi:  0.300nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataKi:  0.540nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataKi:  1nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed