Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50040003
TargetProstaglandin G/H synthase 1(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 140nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 synthesis up to 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50038649(ML-3000 | [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phen...)
Affinity DataIC50: 150nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387596(CHEMBL2057740)
Affinity DataIC50: 410nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 500nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 synthesis up to 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-lipoxygenase(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387594(CHEMBL2057741)
Affinity DataIC50: 510nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotriene B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target5-lipoxygenase(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50038649(ML-3000 | [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phen...)
Affinity DataIC50: 760nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotriene B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target5-lipoxygenase(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387596(CHEMBL2057740)
Affinity DataIC50: 970nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotriene B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387594(CHEMBL2057741)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target5-lipoxygenase(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387595(CHEMBL2057739)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotriene B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target5-lipoxygenase(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387598(CHEMBL2057738)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotriene B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387595(CHEMBL2057739)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50387597(CHEMBL2057214)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed