Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50040099
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at alpha4beta 2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50166908(CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...)
Affinity DataEC50:  0.0600nMAssay Description:Partial agonist activity at alpha4beta 2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at alpha4beta 2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50389167(CHEMBL2062610)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50339001((S)-4-bromophenyl hexahydro-1H-pyrrolo[1,2-a][1,4]...)
Affinity DataIC50: 5.60E+3nMAssay Description:Competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50339002(((3S,9aR)-hexahydro-3-methyl-1H-pyrido[1,2-a]pyraz...)
Affinity DataIC50: 6.10E+3nMAssay Description:Non-competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50389163(CHEMBL2064771)
Affinity DataIC50: 6.90E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50339003((4-chlorophenyl)(4-isopropyl-1,4-diazocan-1-yl)met...)
Affinity DataIC50: 7.00E+3nMAssay Description:Mixed antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50339004(4-chloro-N-((hexahydro-1H-pyrrolizin-7a-yl)methyl)...)
Affinity DataIC50: 7.20E+3nMAssay Description:Mixed antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50389164(CHEMBL2062602)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50389165(CHEMBL2062604)
Affinity DataIC50: 4.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50389166(CHEMBL2062605)
Affinity DataIC50: 4.50E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current after 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed